Synthesis of Zn/SBA-15 from Rice Husk Ash Using Sonochemical Methods as a Quercetin Drug Delivery Matrix

Yulyani Nur Azizah, Haddiana, Tarso Rudiana

Abstract

Quercetin is a drug candidate with bioavailability but currently limited, necessitating the use of a delivery matrix, such as Santa Barbara Amorphous-15 (SBA-15). Rice husk ash, containing a significant amount of silica, served as a precursor in the synthesis of SBA-15, which can be functionalized with nanoparticles, including zinc, using sonochemical methods. Therefore, this study aimed to synthesize Zn/SBA-15 using sonochemistry and evaluate the potential as a drug delivery matrix for quercetin. SBA-15 was formed by sonication of a sodium silicate from rice husk and pore director Pluronic P-123, followed by impregnating Zn at 2%, 4%, and 6% w/w. The characterization of X-ray diffraction (XRD) and fluorescence (XRF) showed a broad peak at 2theta 18-30◦ with Zn levels of 1.89%, 3.69%, and 5.06%. Furthermore, the analysis of transmission electron microscopy (TEM) showed the presence of Zn nanoparticles with a range size of 4-14 nm. In vitro drug delivery experiments were carried out using Zn/SBA-15 at concentrations of 1:1 and 1:2 to quercetin. The in vitro test results for a drug loading of quercetin with Zn/SBA-15 6% 1:1 was 28.30 mg/g. The encapsulation efficiency was 10.96% and the drug release reached 33.64% after 240 minutes.

References

Adrover, M. E., M. Pedernera, M. Bonne, B. Lebeau, V. Bucalá, and L. Gallo (2020). Synthesis and Characterization of Mesoporous SBA-15 and SBA-16 As Carriers to Improve Albendazole Dissolution Rate. Saudi Pharmaceutical Journal, 28(1); 15–24

Alkahtani, S., S. Alarifi, N. H. Aljarba, H. A. Alghamdi, and A. A. Alkahtane (2022). Mesoporous SBA 15 Silica–Loaded Nano-Formulation of Quercetin: A Probable Radio-Sensitizer for Lung Carcinoma. Dose-Response, 20(1); 1–10

Azizah, Y. N., I. Mulyani, D. Wahyuningrum, and D. N. Bima (2020). Synthesis, Characterization and Antioxidant Activity of Kobalt (II)-Hydrazone Complex. Educhemia (Jurnal Kimia dan Pendidikan), 5(2); 119–133

Bai, K., J. Hao, Y. Yang, and A. Qian (2020). The Effect of Hydrothermal Temperature on the Properties of Sba-15 Materials. Heliyon, 6(8); 04436

Bhuyan, D., A. Gogoi, M. Saikia, R. Saikia, and L. Saikia (2015). Facile Synthesis of Gold Nanoparticles on Propylamine Functionalized SBA-15 and Effect of Surface Functionality of Its\ Enhanced Bactericidal Activity against Gram Positive Bacteria. Materials Research Express, 2(7); 075402

Elvira, K., E. Fachriyah, and D. Kusrini (2018). Isolation of Flavonoid Compounds from Eceng Gondok (Eichhornia crassipes) and Antioxidant Tests with Dpph (1, 1-Diphenyl-2-Picrylhydrazyl) Method. Jurnal Kimia Sains dan Aplikasi, 21(4); 187–192

Filiz, A. and S. Balci (2019). Structural Variations in SBA-15 by Copper Incorporation and a Test in Catalytic Wet Peroxide Oxidation of Phenol. Gazi University Journal of Science, 32(1); 91–102

Jarmolińska, S., A. Feliczak Guzik, and I. Nowak (2020). Synthesis, Characterization and Use of Mesoporous Silicas of the Following Types SBA-1, SBA-2, HMM-1 and HMM-2. Materials, 13(19); 4385

Kajbafvala, A., A. Salabat, and A. Salimi (2018). Formulation, Characterization, and In vitro/Ex vivo Evaluation of Quercetin-Loaded Microemulsion for Topical Application. Pharmaceutical Development and Technology, 23(8); 741–750

Kalinowska, M., G. Świderski, M. Matejczyk, and W. Lewandowski (2016). Spectroscopic, Thermogravimetric and Biological Studies of Na (I), Ni (II) and Zn (II) Complexes of Quercetin. Journal of Thermal Analysis and Calorimetry, 126(1); 141–148

Khanh Nguyen, Q. N., N. T. Yen, N. D. Hau, and H. L. Tran (2020). Synthesis and Characterization of Mesoporous Silica SBA-15 and ZnO/SBA-15 Photocatalytic Materials from the Ash of Brickyards. Journal of Chemistry, 2020; 1–8

Kikuchi, S., N. Koga, H. Seino, and S. Ohno (2016). Experimental Study and Kinetic Analysis on Sodium Oxide–Silica Reaction. Journal of Nuclear Science and Technology, 53(5); 682–691

Martínez Carmona, M., M. Colilla, M. L. Ruiz González, J. M. González Calbet, and M. Vallet Regí (2016). High Resolution Transmission Electron Microscopy: A Key Tool to Understand Drug Release from Mesoporous Matrices. Microporous and Mesoporous Materials, 225; 399–410

Mendiguchia, B. S., I. Aiello, and A. Crispini (2015). Zn (II) and Cu (II) Complexes Containing Bioactive O, O-Chelated Ligands: Homoleptic and Heteroleptic Metal-Based Biomolecules. Dalton Transactions, 44(20); 9321–9334

Morales Paredes, C. A., I. Rodríguez Linzán, M. D. Saquete, R. Luque, S. M. Osman, N. Boluda Botella, and R.-D. J. Manuel (2023). Silica-Derived Materials from Agro-Industrial Waste Biomass: Characterization and Comparative Studies. Environmental Research, 231(1); 116002

Nasir, I., N. Ameram, A. Arlina, S. R. Hassan, N. A. C. Zaudin, and J. M. Sapari (2021). A Review of Rice Husk Silica As a Heterogeneous Catalyst Support. Journal of Metals, Materials and Minerals, 31(4); 1–12

Nzereogu, P., A. Omah, F. Ezema, E. Iwuoha, and A. Nwanya (2023). Silica Extraction from Rice Husk: Comprehensive Review and Applications. Hybrid Advances, 4; 100111

Owens, G. J., R. K. Singh, F. Foroutan, M. Alqaysi, C. M. Han, C. Mahapatra, H. W. Kim, and J. C. Knowles (2016). Sol–Gel Based Materials for Biomedical Applications. Progress in Materials Science, 77; 1–79

Patel, P. J., M. C. Gohel, and S. R. Acharya (2014). Exploration of Statistical Experimental Design to Improve Entrapment Efficiency of Acyclovir in Poly (d, l) Lactide Nanoparticles. Pharmaceutical Development and Technology, 19(2); 200–212

Popova, M., I. Trendafilova, Á. Szegedi, J. Mihály, P. Németh, S. G. Marinova, H. A. Aleksandrov, and G. N. Vayssilov (2016). Experimental and Theoretical Study of Quercetin Complexes Formed on Pure Silica and Zn-Modified Mesoporous MCM-41 and SBA-16 Materials. Microporous and Mesoporous Materials, 228; 256–265

Pote, L. L., P. R. R. Sanam, and G. Latumakulita (2022). Synthesis and Characterization of Silica Gel of Waste Agate From The Nian Village of Timor Tengah Utara Regency Using Sol Gel Method. Indonesian Journal of Chemical Research, 7(2); 9–17

Rahmat, N., F. Hamzah, N. Sahiron, M. Mazlan, and M. M. Zahari (2016). Sodium Silicate As Source of Silica for Synthesis of Mesoporous SBA-15. In IOP Conference Series: Materials Science and Engineering, volume 133. IOP Publishing, page 012011

Refat, M. S., R. Z. Hamza, A. M. A. Adam, H. A. Saad, A. A. Gobouri, F. S. Al Harbi, F. A. Al Salmi, T. Altalhi, and S. M. El Megharbel (2021). Quercetin/Zinc Complex and Stem Cells: A New Drug Therapy to Ameliorate Glycometabolic Control and Pulmonary Dysfunction in Diabetes Mellitus: Structural Characterization and Genetic Studies. PLoS One, 16(3); e0246265

Rizzotto, M. (2012). A Search for Antibacterial Agents, volume 10, chapter Metal Complexes As Antimicrobial Agents InTech: Rijeka, Croatia, page 45651

Suyanta, S. and M. Mudasir (2022). Optimizing Rice Husk Silica Mass and Sonication Time for a More Efficient and Environmentally Friendly Synthesis of SBA-15. Indonesian Journal of Chemistry, 22(4); 1090–1106

Thahir, R., A. W. Wahab, N. L. Nafie, and I. Raya (2019). Synthesis of High Surface Area Mesoporous Silica SBA-15 by Adjusting Hydrothermal Treatment Time and the Amount of Polyvinyl Alcohol. Open Chemistry, 17(1); 963–971

Trendafilova, I., A. Szegedi, J. Mihály, G. Momekov, N. Lihareva, and M. Popova (2017). Preparation of Efficient Quercetin Delivery System on Zn-Modified Mesoporous SBA-15 Silica Carrier. Materials Science and Engineering, 73; 285–292

Tsyganenko, A., E. Storozheva, O. Manoilova, T. Lesage, M. Daturi, and J. Lavalley (2000). Brønsted Acidity of Silica Silanol Groups Induced by Adsorption of Acids. Catalysis Letters, 70; 159–163

Uskoković Marković, S., M. Milenković, and L. Pavun (2020). Zinc-Quercetin Complex: From Determination to Bioactivity. Acta Agriculturae Serbica, 25(50); 113–120

Wadhwa, K., V. Kadian, V. Puri, B. Y. Bhardwaj, A. Sharma, R. Pahwa, R. Rao, M. Gupta, and I. Singh (2022). New Insights into Quercetin Nanoformulations for Topical Delivery. mPhytomedicine Plus, 2(2); 100257

Xiao, L., G. Luo, Y. Tang, and P. Yao (2018). Quercetin and Iron Metabolism: What We Know and What We Need to Know. Food and chemical toxicology, 114; 190–203

Zaharudin, N. S., E. D. M. Isa, H. Ahmad, M. B. A. Rahman, and K. Jumbri (2020). Functionalized Mesoporous Silica Nanoparticles Templated by Pyridinium Ionic Liquid for Hydrophilic and Hydrophobic Drug Release Application. Journal of Saudi Chemical Society, 24(3); 289–302

Zhixiong, L., N. Wei, W. Hua, and G. Wengui (2014). Direct Syntheses of Cu-Zn-Zr/SBA-15 Mesoporous Catalysts for CO2 Hydrogenation to Methanol. Chemical Journal of Chinese Universities-Chinese, 35(12); 2616–2623

Authors

Yulyani Nur Azizah
yulyani@uinjkt.ac.id (Primary Contact)
Haddiana
Tarso Rudiana
Author Biography

Tarso Rudiana, Department of Chemistry, Faculty of Science and Technology, Islamic State University Syarif Hidayatullah Jakarta, Tangerang, 15412, Indonesia

1Department of Chemistry, Faculty of Science and Technology, Islamic State University Syarif Hidayatullah Jakarta, Tangerang, 15412, Indonesia

2Department of Chemistry, Faculty of Math and Science, Universitas Mathla’ul Anwar, Padeglang, 42273, Indonesia

Nur Azizah, Y., Haddiana, & Rudiana, T. . (2024). Synthesis of Zn/SBA-15 from Rice Husk Ash Using Sonochemical Methods as a Quercetin Drug Delivery Matrix. Science and Technology Indonesia, 9(2), 480–486. https://doi.org/10.26554/sti.2024.9.2.480-486

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