Synthesis of Zn/SBA-15 from Rice Husk Ash Using Sonochemical Methods as a Quercetin Drug Delivery Matrix

Yulyani Nur Azizah, Haddiana, Tarso Rudiana


Quercetin is a drug candidate with bioavailability but currently limited, necessitating the use of a delivery matrix, such as Santa Barbara Amorphous-15 (SBA-15). Rice husk ash, containing a significant amount of silica, served as a precursor in the synthesis of SBA-15, which can be functionalized with nanoparticles, including zinc, using sonochemical methods. Therefore, this study aimed to synthesize Zn/SBA-15 using sonochemistry and evaluate the potential as a drug delivery matrix for quercetin. SBA-15 was formed by sonication of a sodium silicate from rice husk and pore director Pluronic P-123, followed by impregnating Zn at 2%, 4%, and 6% w/w. The characterization of X-ray diffraction (XRD) and fluorescence (XRF) showed a broad peak at 2theta 18-30◦ with Zn levels of 1.89%, 3.69%, and 5.06%. Furthermore, the analysis of transmission electron microscopy (TEM) showed the presence of Zn nanoparticles with a range size of 4-14 nm. In vitro drug delivery experiments were carried out using Zn/SBA-15 at concentrations of 1:1 and 1:2 to quercetin. The in vitro test results for a drug loading of quercetin with Zn/SBA-15 6% 1:1 was 28.30 mg/g. The encapsulation efficiency was 10.96% and the drug release reached 33.64% after 240 minutes.


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Yulyani Nur Azizah (Primary Contact)
Tarso Rudiana
Author Biography

Tarso Rudiana, Department of Chemistry, Faculty of Science and Technology, Islamic State University Syarif Hidayatullah Jakarta, Tangerang, 15412, Indonesia

1Department of Chemistry, Faculty of Science and Technology, Islamic State University Syarif Hidayatullah Jakarta, Tangerang, 15412, Indonesia

2Department of Chemistry, Faculty of Math and Science, Universitas Mathla’ul Anwar, Padeglang, 42273, Indonesia

Nur Azizah, Y., Haddiana, & Rudiana, T. . (2024). Synthesis of Zn/SBA-15 from Rice Husk Ash Using Sonochemical Methods as a Quercetin Drug Delivery Matrix. Science and Technology Indonesia, 9(2), 480–486.

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