A Comprehensive Review on the Biological Activities, Usage Areas, Chemical and Phenolic Compositions of Lycium barbarum Used in Traditional Medicine Practices
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Keywords:
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Anticancer, Antimicrobial, Antioxidant, Chinese Wolfberry, Goji Berry, Phenolics
Abstract
Plants are organic substances extensively utilized in conventional medicinal procedures. We conducted a comprehensive review of the literature to assemble information on the biological activities, areas of use, total phenolic and flavonoid concentrations, as well as the chemical and phenolic compositions of Lycium barbarum L. The literature investigation revealed that Lycium barbarum has been extensively studied for its antioxidant, antibacterial, and anticancer properties. Furthermore, it was observed that various components of the plant, including the fruit, leaves, flower, root, and bark, were utilized for distinct purposes. Furthermore, it was observed that the chemical and phenolic compositions documented in it exhibited variations depending on the specific parts that were utilized. Chlorogenic acid, p-coumaric acid and ferulic acid are common compounds found in the leaves, flowers and fruit parts of the plant. It is thought that it will be an important material in future studies because it is a source of phenolic compounds reported in the plant. Therefore, L. barbarum is believed to have significant potential as a natural resource in the development of pharmacological strategies.
References
Ahmad, Z., B. Özdemir, M. Sevindik, E. C. Eraslan, Z. Selamoglu, and C. Bal (2023). Phenolic Compound and Antioxidant Potential of Hebeloma sinapizans Mushroom. AgroLife Scientific Journal, 12(2); 12–17
Altintas, A., M. Kosar, N. Kirimer, K. H. C. Baser, and B. Demirci (2006). Composition of the Essential Oils of Lycium barbarum and L. ruthenicum Fruits. Chemistry of Natural Compounds, 42; 24–25
Amagase, H. and N. R. Farnsworth (2011). A Review of Botanical Characteristics, Phytochemistry, Clinical Relevance in Efficacy and Safety of Lycium barbarum Fruit (Goji). Food Research International, 44(7); 1702–1717
Baba, H., M. Sevindik, M. Dogan, and H. Akgül (2020). Antioxidant, Antimicrobial Activities and Heavy Metal Contents of Some Myxomycetes. Fresenius Environmental Bulletin, 29(09); 7840–7846
Bal, C., M. Sevindik, H. Akgul, and Z. Selamoglu (2019). Oxidative Stress Index and Antioxidant Capacity of Lepista nuda Collected from Gaziantep/Turkey. Sigma Journal of Engineering and Natural Sciences, 37(1); 1–5
Benchennouf, A., S. Grigorakis, S. Loupassaki, and E. Kokkalou (2017). Phytochemical Analysis and Antioxidant Activity of Lycium barbarum (Goji) Cultivated in Greece. Pharmaceutical Biology, 55(1); 596–602
Byambasuren, S. E., J. Wang, and G. Gaudel (2019). Medicinal Value of Wolfberry (Lycium barbarum L.). Journal of Medicinal Plants Studies, 7(4); 90–97
Chen, F., Y. Su, F. Zhang, and Y. Guo (2015). Low-Temperature Headspace-Trap Gas Chromatography with Mass Spectrometry for the Determination of Trace Volatile Compounds from the Fruit of Lycium barbarum L. Journal of Separation Science, 38(4); 670–676
Dogan, M., F. S. Mohammed, I. Uysal, K. Mencik, E. KIna, M. Pehlivan, and M. Sevindik (2023). Total Antioxidant Status, Antimicrobial and Antiproliferative Potentials of Viola odorata (Fragrant Violet). Journal of Faculty of Pharmacy of Ankara University, 47(3); 784–791
Dong, J. Z., W. S. Gao, D. Y. Lu, and Y. Wang (2011). Simultaneous Extraction and Analysis of Four Polyphenols from Leaves of Lycium barbarum L. Journal of Food Biochemistry, 35(3); 914–931
Donno, D., G. L. Beccaro, M. G. Mellano, A. K. Cerutti, and G. Bounous (2015). Goji Berry Fruit (Lycium Spp.): Antioxidant Compound Fingerprint and Bioactivity Evaluation. Journal of Functional Foods, 18; 1070–1085
El-Chaghaby, G. A., F. S. Mohammed, S. Rashad, I. Uysal, O. Kocer, O. Lekesiz, M. Dogan, A. E. Sabik, and M. Sevindik (2024). Genus Hypericum: General Properties, Chemical Contents and Biological Activities. Egyptian Journal of Botany, 64(1); 1–26
Eraslan, E. C., D. Altuntas, H. Baba, C. Bal, H. Akgül, I. Akata, and M. Sevindik (2021). Some Biological Activities and Element Contents of Ethanol Extract of Wild Edible Mushroom Morchella esculenta. Sigma Journal of Engineering and Natural Sciences, 39(1); 24–28
Fıt, N. I., F. Chirila, G. Nadaş, E. Pall, and R. Muresan (2013). Comparative Testing of Antimicrobial Activity of Aqueous Extracts of Aloe vera and Lycium barbarium. Bulletin of the University of Agricultural Sciences & Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 70(1); 72–76
Georgiev, K. D., I. J. Slavov, and I. A. Iliev (2019). Synergistic Growth Inhibitory Effects of Lycium barbarum (Goji Berry) Extract with Doxorubicin Against Human Breast Cancer Cells. Journal of Pharmacy and Pharmacology Research, 3(3); 51–58
Ilic, T., M. Dodevska, M. Marcetic, D. Bozic, I. Kodranov, and B. Vidovic (2020). Chemical Characterization, Antioxidant and Antimicrobial Properties of Goji Berries Cultivated in Serbia. Foods, 9(11); 1614
Islam, T., X. Yu, T. S. Badwal, and B. Xu (2017). Comparative Studies on Phenolic Profiles, Antioxidant Capacities and Carotenoid Contents of Red Goji Berry (Lycium barbarum) and Black Goji Berry (Lycium ruthenicum). Chemistry Central Journal, 11; 1–8
Jabbar, S., M. Abid, and X. Zeng (2014). Nutritional, Phytochemical Characterization and Antioxidant Capacity of Ningxia Wolfberry (Lycium barbarum L.). Journal of the Chemical Society of Pakistan, 36(6); 1079
Jiang, L. F. (2014). Preparation and Antioxidant Activity of Lycium barbarum Oligosaccharides. Carbohydrate Polymers, 99; 646–648
Ju, Y., Y. Wang, L. Ma, L. Kang, H. Liu, X. Ma, and D. Zhao (2023). Comparative Analysis of Polyphenols in Lycium barbarum Fruits Using UPLC-IM-QTOF-MS. Molecules, 28(13); 4930
Kafkaletou, M., M. V. Christopoulos, G. Tsaniklidis, I. Papadakis, D. Ioannou, C. Tzoutzoukou, and E. Tsantili. (2018). Nutritional Value and Consumer-Perceived Quality of Fresh Goji Berries (Lycium barbarum L. and L. chinense L.) from Plants Cultivated in Southern Europe. Fruits, 73(1), 5–12.
Kahraman, Y. E., and Y. Calıskan. (2024). A Financial Perspective on the Pharmaceutical Industry. Prospects in Pharmaceutical Sciences, 22(1), 23–31.
Kalkan, M., A. Aygan, N. Cömlekcioglu, and U. Cömlekcioglu. (2023). Olea Europaea Yapraklarinin Bazi Biyoaktif Özelliklerinin Arastirilimasi, Antimikrobiyal ve Enzim Inhibisyon Etkinglinin Incelenmesi. Turkish Journal of Agriculture-Food Science and Technology, 11(3), 496–504.
Karalti, I., E. C. Eraslan, B. G. O. Saridogan, I. Akata, and M. Sevindik. (2022). Total Antioxidant, Antimicrobial, Antiproliferative Potentials and Element Contents of Wild Mushroom Candolleomyces candolleanus (Agaricomycetes) from Turkey. International Journal of Medicinal Mushrooms, 24(12), 69–76.
Korkmaz, A. I., H. Akgul, M. Sevindik, and Z. Selamoglu. (2018). Study on Determination of Bioactive Potentials of Certain Lichens. Acta Alimentaria, 47(1), 80–87.
Korkmaz, N., A. Dayangaç, and M. Sevindik. (2021). Antioxidant, Antimicrobial and Antiproliferative Activities of Galium Aparine. Journal of Faculty of Pharmacy of Ankara University, 45(3), 554–564.
Krupodorova, T., V. Barshteyn, G. Al-Maali, and M. Sevindik. (2022). Requirements for Vegetative Growth of Hohenbuehelia myxotricha and Its Antimycotic Activity. Polish Journal of Natural Sciences, 37(1), 75–92.
Krupodorova, T., V. Barshteyn, V. Tsygankova, M. Sevindik, and Y. Blume. (2024). Strain-Specific Features of Pleurotus ostreatus Growth In Vitro and Some of Its Biological Activities. BMC Biotechnology, 24(1), 9.
Krupodorova, T., and M. Sevindik. (2020). Antioxidant Potential and Some Mineral Contents of Wild Edible Mushroom Ramaria stricta. AgroLife Scientific Journal, 9(1), 186–191.
Kwok, S. S., Y. Bu, A. C. Y. Lo, T. C. Y. Chan, K. F. So, J. S. M. Lai, and K. C. Shih. (2019). A Systematic Review of Potential Therapeutic Use of Lycium barbarum Polysaccharides in Disease. BioMed Research International, 2019(1), 4615745.
Latifani, S., A. N. Fitriani, K. S. Paniroy, Maesayani, J. Freddy, and O. R. Adianingsih. (2024). Enhanced Anti-Inflammatory Activity of Kaempferia galanga Extract by Solid Self-Nanoemulsifying Drug Delivery System and Its Development in Fast Disintegrating Tablet. Science and Technology Indonesia, 9(4), 840–850.
Lee, S. R., M. Y. An, H. J. Hwang, J. G. Yoon, and J. A. Cho. (2020). Antioxidant Effect of Lycium barbarum Leaf Through Inflammatory and Endoplasmic Reticulum Stress Mechanism. Antioxidants, 10(1), 20.
Lei, Z., X. Chen, F. Cao, Q. Guo, and J. Wang. (2022). Phytochemicals and Bioactivities of Goji (Lycium barbarum L. and Lycium chinense Mill.) Leaves and Their Potential Applications in the Food Industry: A Review. International Journal of Food Science & Technology, 57(3), 1451–1461.
Li, R., S. Qu, M. Qin, L. Huang, Y. Huang, Y. Du, and K. F. So. (2023). Immunomodulatory and Antiviral Effects of Lycium barbarum Glycopeptide on Influenza A Virus Infection. Microbial Pathogenesis, 176, 106030.
Lu, J., H. Li, J. Quan, W. An, J. Zhao, and W. Xi. (2017). Identification of Characteristic Aroma Volatiles of Ningxia Goji Berries (Lycium barbarum L.) and Their Developmental Changes. International Journal of Food Properties, 20(1), 214–227.
Lu, Y., S. Guo, F. Zhang, H. Yan, D. W. Qian, H. Q. Wang, and J. A. Duan. (2019). Comparison of Functional Components and Antioxidant Activity of Lycium barbarum L. Fruits From Different Regions in China. Molecules, 24(12), 2228.
Ma, Q., R. Zhai, X. Xie, T. Chen, Z. Zhang, H. Liu, and J. Li. (2022). Hypoglycemic Effects of Lycium barbarum Polysaccharide in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota. Frontiers in Nutrition, 9, 916271.
Ma, R. H., X. X. Zhang, Z. J. Ni, K. Thakur, W. Wang, Y. M. Yan, and Z. J. Wei. (2023). Lycium barbarum (Goji) as Functional Food: A Review of Its Nutrition, Phytochemical Structure, Biological Features, and Food Industry Prospects. Critical Reviews in Food Science and Nutrition, 63(30), 10621–10635.
Magalhaes, V., A. R. Silva, B. Silva, X. Zhang, and A. C. Dias. (2022). Comparative Studies on the Anti-Neuroinflammatory and Antioxidant Activities of Black and Red Goji Berries. Journal of Functional Foods, 92, 105038.
Magiera, S., and M. Zaręba. (2015). Chromatographic Determination of Phenolic Acids and Flavonoids in Lycium barbarum L. and Evaluation of Antioxidant Activity. Food Analytical Methods, 8, 2665–2674.
Mao, F., B. Xiao, Z. Jiang, J. Zhao, X. Huang, and J. Guo. (2011). Anticancer Effect of Lycium barbarum Polysaccharides on Colon Cancer Cells Involves G0/G1 Phase Arrest. Medical Oncology, 28, 121–126.
Mocan, A., F. Cairone, M. Locatelli, F. Cacciagrano, S. Carradori, D. C. Vodnar, and S. Cesa. (2019). Polyphenols From Lycium barbarum (Goji) Fruit European Cultivars at Different Maturation Steps: Extraction, HPLC-DAD Analyses, and Biological Evaluation. Antioxidants, 8(11), 562.
Mocan, A., C. Moldovan, G. Zengin, O. Bender, M. Locatelli, M. Simirgiotis, and G. Crisan. (2018). UHPLC-QTOF-MS Analysis of Bioactive Constituents From Two Romanian Goji (Lycium barbarum L.) Berries Cultivars and Their Antioxidant, Enzyme Inhibitory, and Real-Time Cytotoxicological Evaluation. Food and Chemical Toxicology, 115, 414–424.
Mocan, A., L. Vlase, O. Raita, D. Hanganu, R. Paltinean, S. Dezsi, and G. Crisan. (2015a). Comparative Studies on Antioxidant Activity and Polyphenolic Content of Lycium barbarum L. and Lycium chinense Mill. Leaves. Pak. J. Pharm. Sci., 28(4), 1511–1515.
Mocan, A., L. Vlase, D. C. Vodnar, C. Bischin, D. Hanganu, A. M. Gheldiu, and G. Crisan. (2014). Polyphenolic Content, Antioxidant and Antimicrobial Activities of Lycium barbarum L. and Lycium chinense Mill. Leaves. Molecules, 19(7), 10056–10073.
Mocan, A., L. Vlase, D. C. Vodnar, A. M. Gheldiu, R. Oprean, and G. Crisan (2015b). Antioxidant, Antimicrobial Effects and Phenolic Profile of Lycium barbarum L. Flowers. Molecules, 20(8); 15060–15071.
Mohammed, F. S., S. Günal, M. Pehlivan, M. Dogan, M. Sevindik, and H. Akgül (2020). Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa. Gazi University Journal of Science, 33(4); 670–677.
Mohammed, F. S., N. Korkmaz, M. Dogan, A. E. Sabik, and M. Sevindik (2021). Some Medicinal Properties of Glycyrrhiza glabra (Licorice). Journal of Faculty of Pharmacy of Ankara University, 45(3); 524–534.
Mohammed, F. S., M. Pehlivan, and M. Sevindik (2019). Antioxidant, Antibacterial and Antifungal Activities of Different Extracts of Silybum marianum Collected From Duhok (Iraq). International Journal of Secondary Metabolite, 6(4); 317–322.
Mohammed, F. S., M. Sevindik, and I. Uysal (2023). Total Phenolic, Flavonoid, Protein Contents and Biological Activities of Wild Mustard. Acta Alimentaria, 52(3); 449–457.
Mohammed, F. S., M. Sevindik, I. Uysal, C. Cesko, and H. Korai (2024). Chemical Composition, Biological Activities, Uses, Nutritional and Mineral Contents of Cumin (Cuminum cyminum). Measurement: Food, 14(June); 100157.
Mohammed, F. S., M. Sevindik, I. Uysal, E. Sevindik, and H. Akgül (2022). A Natural Material for Suppressing the Effects of Oxidative Stress: Biological Activities of Alcea kurdica. Biology Bulletin, 49(Suppl 2); S59–S66.
Nardi, G. M., A. G. F. Januario, C. G. Freire, F. Megiolaro, K. Schneider, M. R. A. Perazzoli, and C. Locatelli (2016). Anti-Inflammatory Activity of Berry Fruits in Mice Model of Inflammation Is Based on Oxidative Stress Modulation. Pharmacognosy Research, 8(1); 42.
Nzeuwa, I. B. Y., F. Nea, J. Makemteu, G. M. N. Neubi, F. D. Mabou, J. A. N. Kenfack, and G. Sun (2022). Comparative Study of Polyphenols Quantification, Total Phenolic Content, and Antioxidant Activities of the Fruits of Three Plants of the Family of Solanaceae: Lycium ruthenicum, Lycium barbarum, and Lycium chinense. Investigational Medicinal Chemistry and Pharmacology, 5(2); 67.
Özcandır, A., F. S. Mohammed, M. Sevindik, C. Aykurt, Z. Selamoglu, and H. Akgül (2024). Phenolic Composition, Total Antioxidant, Antiradical and Antimicrobial Potential of Endemic Glaucium alakirensis. Sigma Journal of Engineering and Natural Sciences, 42(1); 42–48.
Ozkan, E. E., T. Y. Ozden, G. G. Toplan, and A. Mat (2018). Phenolic Content and Biological Activities of Lycium barbarum L (Solanaceae) Fruits (Goji Berries) Cultivated in Konya, Turkey. Tropical Journal of Pharmaceutical Research, 17(10); 2047–2053.
Pollini, L., A. Riccio, C. Juan, C. Tringaniello, F. Ianni, F. Blasi, and L. Cossignani (2020). Phenolic Acids From Lycium barbarum Leaves: In Vitro and In Silico Studies of the Inhibitory Activity Against Porcine Pancreatic α-Amylase. Processes, 8(11); 1388.
Potterat, O. (2010). Goji (Lycium barbarum and L. chinense): Phytochemistry, Pharmacology and Safety in the Perspective of Traditional Uses and Recent Popularity. Planta Medica, 76(1); 7–19.
Protti, M., I. Gualandi, R. Mandrioli, S. Zappoli, D. Tonelli, and L. Mercolini (2017). Analytical Profiling of Selected Antioxidants and Total Antioxidant Capacity of Goji (Lycium Spp.) Berries. Journal of Pharmaceutical and Biomedical Analysis, 143; 252–260.
Qian, D., Y. Zhao, G. Yang, and L. Huang (2017). Systematic Review of Chemical Constituents in the Genus Lycium (Solanaceae). Molecules, 22(6); 911.
Segmenoglu, M. S. and M. Sevindik (2024). Antioxidant and Antimicrobial Potentials of Functional Food Arum dioscoridis. Sigma Journal of Engineering and Natural Sciences, 42(1); 116–120.
Sevindik, M., H. Akgul, I. Akata, H. Alli, and Z. Selamoglu (2017). Fomitopsis pinicola in Healthful Dietary Approach and Their Therapeutic Potentials. Acta Alimentaria, 46(4); 464–469.
Sevindik, M., A. Gürgen, V. T. Khassanov, and C. Bal (2024). Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis. Foods, 13(10); 1560.
Sevindik, M., A. Rasul, G. Hussain, H. Anwar, M. K. Zahoor, I. Sarfraz, and Z. Selamoglu (2018). Determination of Anti-Oxidative, Anti-Microbial Activity and Heavy Metal Contents of Leucoagaricus leucothites. Pakistan Journal of Pharmaceutical Sciences, 31(5 (Supplementary)); 2163–2168.
Shang, Y. F., T. H. Zhang, K. Thakur, J. G. Zhang, C. L. A. Cespedes-Acuña, and Z. J. Wei (2022). HPLC-MS/MS Targeting Analysis of Phenolics Metabolism and Antioxidant Activity of Extractions From Lycium barbarum and Its Meal Using Different Methods. Food Science and Technology, 42(1); 1–8.
Sholikhah, E. N., T. Wiyono, and W. R. Pratiwi (2024). Metabolic Profiling, Antioxidant, and Anti-Lipase Activity From Combined Leaves Extracts of Tamarindus indica and Murraya paniculata: A Simplex Lattice Design Approach. Science and Technology Indonesia, 9(4); 828–839.
Skenderidis, P., D. Lampakis, I. Giavasis, S. Leontopoulos, K. Petrotos, C. Hadjichristodoulou, and A. Tsakalof (2019a). Chemical Properties, Fatty-Acid Composition, and Antioxidant Activity of Goji Berry (Lycium barbarum L. and Lycium chinense Mill.) Fruits. Antioxidants, 8(3); 60.
Skenderidis, P., C. Mitsagga, I. Giavasis, K. Petrotos, D. Lampakis, S. Leontopoulos, and A. Tsakalof (2019b). The in Vitro Antimicrobial Activity Assessment of Ultrasound Assisted Lycium barbarum Fruit Extracts and Pomegranate Fruit Peels. Journal of Food Measurement and Characterization, 13; 2017–2031.
Taneva, I. and Z. Zlatev (2020). Total Phenolic Content and Antioxidant Activity of Yoghurt With Goji Berries (Lycium barbarum). Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry, 21(1); 125–131.
Tian, X., T. Liang, Y. Liu, G. Ding, F. Zhang, and Z. Ma (2019). Extraction, Structural Characterization, and Biological Functions of Lycium barbarum Polysaccharides: A Review. Biomolecules, 9(9); 389.
Wang, C. C., S. C. Chang, B. S. Inbaraj, and B. H. Chen (2010). Isolation of Carotenoids, Flavonoids and Polysaccharides From Lycium barbarum L. and Evaluation of Antioxidant Activity. Food Chemistry, 120(1); 184–192.
Widyastuti, W., E. Elmitra, E. S. Wardi, and D. Agustin (2024). Plectranthus scutellarioides (L.) R.Br. Leaf Extract as Sunscreen, Skin Lightening, and Antiaging. Science and Technology Indonesia, 9(3); 745–755.
Wojdyło, A., P. Nowicka, and P. Bąbelewski (2018). Phenolic and Carotenoid Profile of New Goji Cultivars and Their Anti-Hyperglycemic, Anti-Aging and Antioxidant Properties. Journal of Functional Foods, 48; 632–642.
Xiao Ning, D., X. Hui Juan, H. Pan Pan, and D. Jin Xia (2015). Diversity and Antimicrobial Activity of Endophytic Bacteria Isolated From Lycium barbarum of Ningxia. Microbiology China, 42(9); 1779–1787.
Xu, Y., Z. Zang, Q. Zhang, T. Wang, J. Shang, X. Huang, and F. Wan (2022). Characteristics and Quality Analysis of Radio Frequency-Hot Air Combined Segmented Drying of Wolfberry (Lycium barbarum). Foods, 11(11); 1645.
Yao, R., M. Heinrich, and C. S. Weckerle (2018). The Genus Lycium as Food and Medicine: A Botanical, Ethnobotanical and Historical Review. Journal of Ethnopharmacology, 212; 50–66.
Yossa Nzeuwa, I. B., B. Guo, T. Zhang, L. Wang, Q. Ji, H. Xia, and G. Sun (2019). Comparative Metabolic Profiling of Lycium Fruits (Lycium barbarum and Lycium chinense) From Different Areas in China and From Nepal. Journal of Food Quality, 2019(1); 4396027.
Zhang, M., F. Wang, R. Liu, X. Tang, Q. Zhang, and Z. Zhang (2014). Effects of Superfine Grinding on Physicochemical and Antioxidant Properties of Lycium barbarum Polysaccharides. LWT-Food Science and Technology, 58(2); 594–601.
Zhou, W., T. Yang, W. Xu, Y. Huang, L. Ran, Y. Yan, and Y. Cao (2022). The Polysaccharides From the Fruits of Lycium barbarum L. Confer Anti-Diabetic Effect by Regulating Gut Microbiota and Intestinal Barrier. Carbohydrate Polymers, 291; 119626.
Altintas, A., M. Kosar, N. Kirimer, K. H. C. Baser, and B. Demirci (2006). Composition of the Essential Oils of Lycium barbarum and L. ruthenicum Fruits. Chemistry of Natural Compounds, 42; 24–25
Amagase, H. and N. R. Farnsworth (2011). A Review of Botanical Characteristics, Phytochemistry, Clinical Relevance in Efficacy and Safety of Lycium barbarum Fruit (Goji). Food Research International, 44(7); 1702–1717
Baba, H., M. Sevindik, M. Dogan, and H. Akgül (2020). Antioxidant, Antimicrobial Activities and Heavy Metal Contents of Some Myxomycetes. Fresenius Environmental Bulletin, 29(09); 7840–7846
Bal, C., M. Sevindik, H. Akgul, and Z. Selamoglu (2019). Oxidative Stress Index and Antioxidant Capacity of Lepista nuda Collected from Gaziantep/Turkey. Sigma Journal of Engineering and Natural Sciences, 37(1); 1–5
Benchennouf, A., S. Grigorakis, S. Loupassaki, and E. Kokkalou (2017). Phytochemical Analysis and Antioxidant Activity of Lycium barbarum (Goji) Cultivated in Greece. Pharmaceutical Biology, 55(1); 596–602
Byambasuren, S. E., J. Wang, and G. Gaudel (2019). Medicinal Value of Wolfberry (Lycium barbarum L.). Journal of Medicinal Plants Studies, 7(4); 90–97
Chen, F., Y. Su, F. Zhang, and Y. Guo (2015). Low-Temperature Headspace-Trap Gas Chromatography with Mass Spectrometry for the Determination of Trace Volatile Compounds from the Fruit of Lycium barbarum L. Journal of Separation Science, 38(4); 670–676
Dogan, M., F. S. Mohammed, I. Uysal, K. Mencik, E. KIna, M. Pehlivan, and M. Sevindik (2023). Total Antioxidant Status, Antimicrobial and Antiproliferative Potentials of Viola odorata (Fragrant Violet). Journal of Faculty of Pharmacy of Ankara University, 47(3); 784–791
Dong, J. Z., W. S. Gao, D. Y. Lu, and Y. Wang (2011). Simultaneous Extraction and Analysis of Four Polyphenols from Leaves of Lycium barbarum L. Journal of Food Biochemistry, 35(3); 914–931
Donno, D., G. L. Beccaro, M. G. Mellano, A. K. Cerutti, and G. Bounous (2015). Goji Berry Fruit (Lycium Spp.): Antioxidant Compound Fingerprint and Bioactivity Evaluation. Journal of Functional Foods, 18; 1070–1085
El-Chaghaby, G. A., F. S. Mohammed, S. Rashad, I. Uysal, O. Kocer, O. Lekesiz, M. Dogan, A. E. Sabik, and M. Sevindik (2024). Genus Hypericum: General Properties, Chemical Contents and Biological Activities. Egyptian Journal of Botany, 64(1); 1–26
Eraslan, E. C., D. Altuntas, H. Baba, C. Bal, H. Akgül, I. Akata, and M. Sevindik (2021). Some Biological Activities and Element Contents of Ethanol Extract of Wild Edible Mushroom Morchella esculenta. Sigma Journal of Engineering and Natural Sciences, 39(1); 24–28
Fıt, N. I., F. Chirila, G. Nadaş, E. Pall, and R. Muresan (2013). Comparative Testing of Antimicrobial Activity of Aqueous Extracts of Aloe vera and Lycium barbarium. Bulletin of the University of Agricultural Sciences & Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 70(1); 72–76
Georgiev, K. D., I. J. Slavov, and I. A. Iliev (2019). Synergistic Growth Inhibitory Effects of Lycium barbarum (Goji Berry) Extract with Doxorubicin Against Human Breast Cancer Cells. Journal of Pharmacy and Pharmacology Research, 3(3); 51–58
Ilic, T., M. Dodevska, M. Marcetic, D. Bozic, I. Kodranov, and B. Vidovic (2020). Chemical Characterization, Antioxidant and Antimicrobial Properties of Goji Berries Cultivated in Serbia. Foods, 9(11); 1614
Islam, T., X. Yu, T. S. Badwal, and B. Xu (2017). Comparative Studies on Phenolic Profiles, Antioxidant Capacities and Carotenoid Contents of Red Goji Berry (Lycium barbarum) and Black Goji Berry (Lycium ruthenicum). Chemistry Central Journal, 11; 1–8
Jabbar, S., M. Abid, and X. Zeng (2014). Nutritional, Phytochemical Characterization and Antioxidant Capacity of Ningxia Wolfberry (Lycium barbarum L.). Journal of the Chemical Society of Pakistan, 36(6); 1079
Jiang, L. F. (2014). Preparation and Antioxidant Activity of Lycium barbarum Oligosaccharides. Carbohydrate Polymers, 99; 646–648
Ju, Y., Y. Wang, L. Ma, L. Kang, H. Liu, X. Ma, and D. Zhao (2023). Comparative Analysis of Polyphenols in Lycium barbarum Fruits Using UPLC-IM-QTOF-MS. Molecules, 28(13); 4930
Kafkaletou, M., M. V. Christopoulos, G. Tsaniklidis, I. Papadakis, D. Ioannou, C. Tzoutzoukou, and E. Tsantili. (2018). Nutritional Value and Consumer-Perceived Quality of Fresh Goji Berries (Lycium barbarum L. and L. chinense L.) from Plants Cultivated in Southern Europe. Fruits, 73(1), 5–12.
Kahraman, Y. E., and Y. Calıskan. (2024). A Financial Perspective on the Pharmaceutical Industry. Prospects in Pharmaceutical Sciences, 22(1), 23–31.
Kalkan, M., A. Aygan, N. Cömlekcioglu, and U. Cömlekcioglu. (2023). Olea Europaea Yapraklarinin Bazi Biyoaktif Özelliklerinin Arastirilimasi, Antimikrobiyal ve Enzim Inhibisyon Etkinglinin Incelenmesi. Turkish Journal of Agriculture-Food Science and Technology, 11(3), 496–504.
Karalti, I., E. C. Eraslan, B. G. O. Saridogan, I. Akata, and M. Sevindik. (2022). Total Antioxidant, Antimicrobial, Antiproliferative Potentials and Element Contents of Wild Mushroom Candolleomyces candolleanus (Agaricomycetes) from Turkey. International Journal of Medicinal Mushrooms, 24(12), 69–76.
Korkmaz, A. I., H. Akgul, M. Sevindik, and Z. Selamoglu. (2018). Study on Determination of Bioactive Potentials of Certain Lichens. Acta Alimentaria, 47(1), 80–87.
Korkmaz, N., A. Dayangaç, and M. Sevindik. (2021). Antioxidant, Antimicrobial and Antiproliferative Activities of Galium Aparine. Journal of Faculty of Pharmacy of Ankara University, 45(3), 554–564.
Krupodorova, T., V. Barshteyn, G. Al-Maali, and M. Sevindik. (2022). Requirements for Vegetative Growth of Hohenbuehelia myxotricha and Its Antimycotic Activity. Polish Journal of Natural Sciences, 37(1), 75–92.
Krupodorova, T., V. Barshteyn, V. Tsygankova, M. Sevindik, and Y. Blume. (2024). Strain-Specific Features of Pleurotus ostreatus Growth In Vitro and Some of Its Biological Activities. BMC Biotechnology, 24(1), 9.
Krupodorova, T., and M. Sevindik. (2020). Antioxidant Potential and Some Mineral Contents of Wild Edible Mushroom Ramaria stricta. AgroLife Scientific Journal, 9(1), 186–191.
Kwok, S. S., Y. Bu, A. C. Y. Lo, T. C. Y. Chan, K. F. So, J. S. M. Lai, and K. C. Shih. (2019). A Systematic Review of Potential Therapeutic Use of Lycium barbarum Polysaccharides in Disease. BioMed Research International, 2019(1), 4615745.
Latifani, S., A. N. Fitriani, K. S. Paniroy, Maesayani, J. Freddy, and O. R. Adianingsih. (2024). Enhanced Anti-Inflammatory Activity of Kaempferia galanga Extract by Solid Self-Nanoemulsifying Drug Delivery System and Its Development in Fast Disintegrating Tablet. Science and Technology Indonesia, 9(4), 840–850.
Lee, S. R., M. Y. An, H. J. Hwang, J. G. Yoon, and J. A. Cho. (2020). Antioxidant Effect of Lycium barbarum Leaf Through Inflammatory and Endoplasmic Reticulum Stress Mechanism. Antioxidants, 10(1), 20.
Lei, Z., X. Chen, F. Cao, Q. Guo, and J. Wang. (2022). Phytochemicals and Bioactivities of Goji (Lycium barbarum L. and Lycium chinense Mill.) Leaves and Their Potential Applications in the Food Industry: A Review. International Journal of Food Science & Technology, 57(3), 1451–1461.
Li, R., S. Qu, M. Qin, L. Huang, Y. Huang, Y. Du, and K. F. So. (2023). Immunomodulatory and Antiviral Effects of Lycium barbarum Glycopeptide on Influenza A Virus Infection. Microbial Pathogenesis, 176, 106030.
Lu, J., H. Li, J. Quan, W. An, J. Zhao, and W. Xi. (2017). Identification of Characteristic Aroma Volatiles of Ningxia Goji Berries (Lycium barbarum L.) and Their Developmental Changes. International Journal of Food Properties, 20(1), 214–227.
Lu, Y., S. Guo, F. Zhang, H. Yan, D. W. Qian, H. Q. Wang, and J. A. Duan. (2019). Comparison of Functional Components and Antioxidant Activity of Lycium barbarum L. Fruits From Different Regions in China. Molecules, 24(12), 2228.
Ma, Q., R. Zhai, X. Xie, T. Chen, Z. Zhang, H. Liu, and J. Li. (2022). Hypoglycemic Effects of Lycium barbarum Polysaccharide in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota. Frontiers in Nutrition, 9, 916271.
Ma, R. H., X. X. Zhang, Z. J. Ni, K. Thakur, W. Wang, Y. M. Yan, and Z. J. Wei. (2023). Lycium barbarum (Goji) as Functional Food: A Review of Its Nutrition, Phytochemical Structure, Biological Features, and Food Industry Prospects. Critical Reviews in Food Science and Nutrition, 63(30), 10621–10635.
Magalhaes, V., A. R. Silva, B. Silva, X. Zhang, and A. C. Dias. (2022). Comparative Studies on the Anti-Neuroinflammatory and Antioxidant Activities of Black and Red Goji Berries. Journal of Functional Foods, 92, 105038.
Magiera, S., and M. Zaręba. (2015). Chromatographic Determination of Phenolic Acids and Flavonoids in Lycium barbarum L. and Evaluation of Antioxidant Activity. Food Analytical Methods, 8, 2665–2674.
Mao, F., B. Xiao, Z. Jiang, J. Zhao, X. Huang, and J. Guo. (2011). Anticancer Effect of Lycium barbarum Polysaccharides on Colon Cancer Cells Involves G0/G1 Phase Arrest. Medical Oncology, 28, 121–126.
Mocan, A., F. Cairone, M. Locatelli, F. Cacciagrano, S. Carradori, D. C. Vodnar, and S. Cesa. (2019). Polyphenols From Lycium barbarum (Goji) Fruit European Cultivars at Different Maturation Steps: Extraction, HPLC-DAD Analyses, and Biological Evaluation. Antioxidants, 8(11), 562.
Mocan, A., C. Moldovan, G. Zengin, O. Bender, M. Locatelli, M. Simirgiotis, and G. Crisan. (2018). UHPLC-QTOF-MS Analysis of Bioactive Constituents From Two Romanian Goji (Lycium barbarum L.) Berries Cultivars and Their Antioxidant, Enzyme Inhibitory, and Real-Time Cytotoxicological Evaluation. Food and Chemical Toxicology, 115, 414–424.
Mocan, A., L. Vlase, O. Raita, D. Hanganu, R. Paltinean, S. Dezsi, and G. Crisan. (2015a). Comparative Studies on Antioxidant Activity and Polyphenolic Content of Lycium barbarum L. and Lycium chinense Mill. Leaves. Pak. J. Pharm. Sci., 28(4), 1511–1515.
Mocan, A., L. Vlase, D. C. Vodnar, C. Bischin, D. Hanganu, A. M. Gheldiu, and G. Crisan. (2014). Polyphenolic Content, Antioxidant and Antimicrobial Activities of Lycium barbarum L. and Lycium chinense Mill. Leaves. Molecules, 19(7), 10056–10073.
Mocan, A., L. Vlase, D. C. Vodnar, A. M. Gheldiu, R. Oprean, and G. Crisan (2015b). Antioxidant, Antimicrobial Effects and Phenolic Profile of Lycium barbarum L. Flowers. Molecules, 20(8); 15060–15071.
Mohammed, F. S., S. Günal, M. Pehlivan, M. Dogan, M. Sevindik, and H. Akgül (2020). Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa. Gazi University Journal of Science, 33(4); 670–677.
Mohammed, F. S., N. Korkmaz, M. Dogan, A. E. Sabik, and M. Sevindik (2021). Some Medicinal Properties of Glycyrrhiza glabra (Licorice). Journal of Faculty of Pharmacy of Ankara University, 45(3); 524–534.
Mohammed, F. S., M. Pehlivan, and M. Sevindik (2019). Antioxidant, Antibacterial and Antifungal Activities of Different Extracts of Silybum marianum Collected From Duhok (Iraq). International Journal of Secondary Metabolite, 6(4); 317–322.
Mohammed, F. S., M. Sevindik, and I. Uysal (2023). Total Phenolic, Flavonoid, Protein Contents and Biological Activities of Wild Mustard. Acta Alimentaria, 52(3); 449–457.
Mohammed, F. S., M. Sevindik, I. Uysal, C. Cesko, and H. Korai (2024). Chemical Composition, Biological Activities, Uses, Nutritional and Mineral Contents of Cumin (Cuminum cyminum). Measurement: Food, 14(June); 100157.
Mohammed, F. S., M. Sevindik, I. Uysal, E. Sevindik, and H. Akgül (2022). A Natural Material for Suppressing the Effects of Oxidative Stress: Biological Activities of Alcea kurdica. Biology Bulletin, 49(Suppl 2); S59–S66.
Nardi, G. M., A. G. F. Januario, C. G. Freire, F. Megiolaro, K. Schneider, M. R. A. Perazzoli, and C. Locatelli (2016). Anti-Inflammatory Activity of Berry Fruits in Mice Model of Inflammation Is Based on Oxidative Stress Modulation. Pharmacognosy Research, 8(1); 42.
Nzeuwa, I. B. Y., F. Nea, J. Makemteu, G. M. N. Neubi, F. D. Mabou, J. A. N. Kenfack, and G. Sun (2022). Comparative Study of Polyphenols Quantification, Total Phenolic Content, and Antioxidant Activities of the Fruits of Three Plants of the Family of Solanaceae: Lycium ruthenicum, Lycium barbarum, and Lycium chinense. Investigational Medicinal Chemistry and Pharmacology, 5(2); 67.
Özcandır, A., F. S. Mohammed, M. Sevindik, C. Aykurt, Z. Selamoglu, and H. Akgül (2024). Phenolic Composition, Total Antioxidant, Antiradical and Antimicrobial Potential of Endemic Glaucium alakirensis. Sigma Journal of Engineering and Natural Sciences, 42(1); 42–48.
Ozkan, E. E., T. Y. Ozden, G. G. Toplan, and A. Mat (2018). Phenolic Content and Biological Activities of Lycium barbarum L (Solanaceae) Fruits (Goji Berries) Cultivated in Konya, Turkey. Tropical Journal of Pharmaceutical Research, 17(10); 2047–2053.
Pollini, L., A. Riccio, C. Juan, C. Tringaniello, F. Ianni, F. Blasi, and L. Cossignani (2020). Phenolic Acids From Lycium barbarum Leaves: In Vitro and In Silico Studies of the Inhibitory Activity Against Porcine Pancreatic α-Amylase. Processes, 8(11); 1388.
Potterat, O. (2010). Goji (Lycium barbarum and L. chinense): Phytochemistry, Pharmacology and Safety in the Perspective of Traditional Uses and Recent Popularity. Planta Medica, 76(1); 7–19.
Protti, M., I. Gualandi, R. Mandrioli, S. Zappoli, D. Tonelli, and L. Mercolini (2017). Analytical Profiling of Selected Antioxidants and Total Antioxidant Capacity of Goji (Lycium Spp.) Berries. Journal of Pharmaceutical and Biomedical Analysis, 143; 252–260.
Qian, D., Y. Zhao, G. Yang, and L. Huang (2017). Systematic Review of Chemical Constituents in the Genus Lycium (Solanaceae). Molecules, 22(6); 911.
Segmenoglu, M. S. and M. Sevindik (2024). Antioxidant and Antimicrobial Potentials of Functional Food Arum dioscoridis. Sigma Journal of Engineering and Natural Sciences, 42(1); 116–120.
Sevindik, M., H. Akgul, I. Akata, H. Alli, and Z. Selamoglu (2017). Fomitopsis pinicola in Healthful Dietary Approach and Their Therapeutic Potentials. Acta Alimentaria, 46(4); 464–469.
Sevindik, M., A. Gürgen, V. T. Khassanov, and C. Bal (2024). Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis. Foods, 13(10); 1560.
Sevindik, M., A. Rasul, G. Hussain, H. Anwar, M. K. Zahoor, I. Sarfraz, and Z. Selamoglu (2018). Determination of Anti-Oxidative, Anti-Microbial Activity and Heavy Metal Contents of Leucoagaricus leucothites. Pakistan Journal of Pharmaceutical Sciences, 31(5 (Supplementary)); 2163–2168.
Shang, Y. F., T. H. Zhang, K. Thakur, J. G. Zhang, C. L. A. Cespedes-Acuña, and Z. J. Wei (2022). HPLC-MS/MS Targeting Analysis of Phenolics Metabolism and Antioxidant Activity of Extractions From Lycium barbarum and Its Meal Using Different Methods. Food Science and Technology, 42(1); 1–8.
Sholikhah, E. N., T. Wiyono, and W. R. Pratiwi (2024). Metabolic Profiling, Antioxidant, and Anti-Lipase Activity From Combined Leaves Extracts of Tamarindus indica and Murraya paniculata: A Simplex Lattice Design Approach. Science and Technology Indonesia, 9(4); 828–839.
Skenderidis, P., D. Lampakis, I. Giavasis, S. Leontopoulos, K. Petrotos, C. Hadjichristodoulou, and A. Tsakalof (2019a). Chemical Properties, Fatty-Acid Composition, and Antioxidant Activity of Goji Berry (Lycium barbarum L. and Lycium chinense Mill.) Fruits. Antioxidants, 8(3); 60.
Skenderidis, P., C. Mitsagga, I. Giavasis, K. Petrotos, D. Lampakis, S. Leontopoulos, and A. Tsakalof (2019b). The in Vitro Antimicrobial Activity Assessment of Ultrasound Assisted Lycium barbarum Fruit Extracts and Pomegranate Fruit Peels. Journal of Food Measurement and Characterization, 13; 2017–2031.
Taneva, I. and Z. Zlatev (2020). Total Phenolic Content and Antioxidant Activity of Yoghurt With Goji Berries (Lycium barbarum). Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry, 21(1); 125–131.
Tian, X., T. Liang, Y. Liu, G. Ding, F. Zhang, and Z. Ma (2019). Extraction, Structural Characterization, and Biological Functions of Lycium barbarum Polysaccharides: A Review. Biomolecules, 9(9); 389.
Wang, C. C., S. C. Chang, B. S. Inbaraj, and B. H. Chen (2010). Isolation of Carotenoids, Flavonoids and Polysaccharides From Lycium barbarum L. and Evaluation of Antioxidant Activity. Food Chemistry, 120(1); 184–192.
Widyastuti, W., E. Elmitra, E. S. Wardi, and D. Agustin (2024). Plectranthus scutellarioides (L.) R.Br. Leaf Extract as Sunscreen, Skin Lightening, and Antiaging. Science and Technology Indonesia, 9(3); 745–755.
Wojdyło, A., P. Nowicka, and P. Bąbelewski (2018). Phenolic and Carotenoid Profile of New Goji Cultivars and Their Anti-Hyperglycemic, Anti-Aging and Antioxidant Properties. Journal of Functional Foods, 48; 632–642.
Xiao Ning, D., X. Hui Juan, H. Pan Pan, and D. Jin Xia (2015). Diversity and Antimicrobial Activity of Endophytic Bacteria Isolated From Lycium barbarum of Ningxia. Microbiology China, 42(9); 1779–1787.
Xu, Y., Z. Zang, Q. Zhang, T. Wang, J. Shang, X. Huang, and F. Wan (2022). Characteristics and Quality Analysis of Radio Frequency-Hot Air Combined Segmented Drying of Wolfberry (Lycium barbarum). Foods, 11(11); 1645.
Yao, R., M. Heinrich, and C. S. Weckerle (2018). The Genus Lycium as Food and Medicine: A Botanical, Ethnobotanical and Historical Review. Journal of Ethnopharmacology, 212; 50–66.
Yossa Nzeuwa, I. B., B. Guo, T. Zhang, L. Wang, Q. Ji, H. Xia, and G. Sun (2019). Comparative Metabolic Profiling of Lycium Fruits (Lycium barbarum and Lycium chinense) From Different Areas in China and From Nepal. Journal of Food Quality, 2019(1); 4396027.
Zhang, M., F. Wang, R. Liu, X. Tang, Q. Zhang, and Z. Zhang (2014). Effects of Superfine Grinding on Physicochemical and Antioxidant Properties of Lycium barbarum Polysaccharides. LWT-Food Science and Technology, 58(2); 594–601.
Zhou, W., T. Yang, W. Xu, Y. Huang, L. Ran, Y. Yan, and Y. Cao (2022). The Polysaccharides From the Fruits of Lycium barbarum L. Confer Anti-Diabetic Effect by Regulating Gut Microbiota and Intestinal Barrier. Carbohydrate Polymers, 291; 119626.
Authors
Sevindik, M., Uygun, A. E., Uysal, . I., & Sabik, A. E. (2025). A Comprehensive Review on the Biological Activities, Usage Areas, Chemical and Phenolic Compositions of Lycium barbarum Used in Traditional Medicine Practices. Science and Technology Indonesia, 10(1), 173–182. https://doi.org/10.26554/sti.2025.10.1.173-182
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