Tablet Formula Optimization From Helminthostachys Zaylanica Extract Using A Simplex Lattice Design
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Keywords:
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Helmynthostachis zeylanic, Tablet, Optimization, Simplex Lattice Design
Abstract
Helminthostachys zeylanica extract has pharmacological activities such as antioxidant, antiinflamatory, and antihyerucemia. This extract is nontoxic substance from the acute and subchronic toxicity tests. This extract has a potency to be formulated into tablet dosage forms. This study aims to optimize a tablet formula from Helminthostachys zeylanica extract. Disintegrant and binder concentrations were independent variables, while physical properties and dissolution time of the tablets were dependent variables. The tablet was prepared by a wet granulation method. Formula was optimized by Simplex Lattice Design. Physicochemical properties
of granule, physical properties and dissolution of tablet were then analyzed with One Way ANOVA (p = 0.05). Based on granule analysis, specification of physicochemical parameters, such as hausner’s ratio, compressibility index, flowability, repose angle, and water content, met standard British Pharmacopeia. In addition, the starch and PVA concentrations influenced thickness, weight variation, hardness, friability, disintegration time and dissolution of the tablets (p <0.05), except for friability (p> 0.05). Based on this study, the starch and PVA concentrations for the optimum tablet formula were 19.5% and 1.05%, respectively.
References
References
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Bhowmik, D., Chiranjib, B., Yadav, J., Chandira, R.M., KumarK. P, S., 2010. Emerging Trends of Disintegrants used in Formulation of Solid Dosage Form Debjit. Pharm. Lett. 2, 495–504.
Chang, T.C., Chiang, H., Lai, Y.H., Huang, Y.L., Huang, H.C., Liang, Y.C., Liu, H.K., Huang, C., 2019. Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice. BMC Complement. Altern. Med. 19, 1–11. https://doi.org/10.1186/s12906-019-2782-3
Chen, C.C., Huang, Y.L., Yeh, P.Y., Ou, J.C., 2003. Cyclized Geranyl Stilbenes from the Rhizomes of Helminthostachys zeylanica. Planta Med. 69, 964–967. https://doi.org/10.1055/s-2003-45112
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Ermawati, D.E., Sulaiman, S., Purwantini, I., 2017. Optimization Formula of Turmeric (Curcuma longa L.) Extract Chewable with Combination of Mannitol-Lactose as Filler Based on Simplex Lattice Design. JPSCR J. Pharm. Sci. Clin. Res. 2, 53–65. https://doi.org/10.20961/jpscr.v2i01.5284
Fitrya, F., Fithry, N.A., Muharni, 2017. A subchronic toxicity test of ethanol extract from Tunjuk langit rhizome (Helminthostachys Zeylanica) on albino rats, Rattus noverticus (Wistar strain). Asian J. Pharm. Clin. Res. 10. https://doi.org/10.22159/ajpcr.2017.v10i2.15563
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Hardenia, S., Darwhekar, G.., Singh, R.., 2016. Optimization of Fast Dissolving Tablets of Promethazine Theoclate with Effervescent Technology using 32 Full Factorial Design. Int. J. Pharm. Sci. Res. 7, 5115–5124. https://doi.org/10.13040/IJPSR.0975-8232.7(12).5115-24
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Rowe, R.C., Sheskey, P.J., Quinn, M.E., 2009. Handbook of Pharmaceutical Excipient, Sixth. ed. Pharmaceutical Press and American Pharmacists Association, Washington.
Saxena, S.K., 2004. The Joint FAO/WHO Expert Committee on Food Additives, 61st Meeting, in: Polyvinil Alcohol (PVA): Chemical and Technical Assessment (CTA). pp. 1–3.
Son, G.H., Lee, H.J., Na, Y.G., Lee, H.K., Kim, Sung Jin, Huh, H.W., Kim, K.T., Kang, J.S., Kim, Y.H., Myung, C.S., Yoon, M.H., Kim, Seok Jin, Cho, H.S., Lee, J.Y., Cho, C.W., 2019. Formulation and statistical analysis of an herbal medicine tablet containing Morus alba leaf extracts. J. Pharm. Investig. 49, 625–634. https://doi.org/10.1007/s40005-018-00417-9
Su, L.H., Li, Y.P., Li, H.M., Dai, W.F., Liu, D., Cao, L., Li, R.T., 2016. Anti-inflammatory prenylated flavonoids from Helminthostachys zeylanica. Chem. Pharm. Bull. 64, 497–501. https://doi.org/10.1248/cpb.c15-00661
Suja, S.R., Latha, P.G., Pushpangadan, P., Rajasekharan, S., 2004. Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats. J. Ethnopharmacol. 92, 61–66. https://doi.org/10.1016/j.jep.2004.01.019
Wu, K.C., Kao, C.P., Ho, Y.L., Chang, Y.S., 2017. Quality control of the root and rhizome of Helminthostachys zeylanica (Daodi-Ugon) by HPLC using Quercetin and Ugonins as markers. Molecules 22, 1–10. https://doi.org/10.3390/molecules22071115
Zade, P.S., Kawtikwar, P.S., Sakarkar, D.M., 2009. Formulation, evaluation and optimization of fast dissolving tablet containing Tizanidine Hydrochloride. Int. J. PharmTech Res. 1, 34–42.
Adeleye, O.A., Femi-Oyewo, M.N., Odeniyi, M.A., 2015. Effect of compression pressure on mechanical and release properties of tramadol matrix tablets. Curr. Issues Pharm. Med. Sci. 28, 120–125. https://doi.org/10.1515/cipms-2015-0057
Bhowmik, D., Chiranjib, B., Yadav, J., Chandira, R.M., KumarK. P, S., 2010. Emerging Trends of Disintegrants used in Formulation of Solid Dosage Form Debjit. Pharm. Lett. 2, 495–504.
Chang, T.C., Chiang, H., Lai, Y.H., Huang, Y.L., Huang, H.C., Liang, Y.C., Liu, H.K., Huang, C., 2019. Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice. BMC Complement. Altern. Med. 19, 1–11. https://doi.org/10.1186/s12906-019-2782-3
Chen, C.C., Huang, Y.L., Yeh, P.Y., Ou, J.C., 2003. Cyclized Geranyl Stilbenes from the Rhizomes of Helminthostachys zeylanica. Planta Med. 69, 964–967. https://doi.org/10.1055/s-2003-45112
El Ridhasya, F., Rahim, N., Almurdani, M., Hendra, R., Teruna, H.Y., 2020. Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae). Pharmacogn. J. 12, 223–226. https://doi.org/10.5530/pj.2020.12.33
Ermawati, D.E., Sulaiman, S., Purwantini, I., 2017. Optimization Formula of Turmeric (Curcuma longa L.) Extract Chewable with Combination of Mannitol-Lactose as Filler Based on Simplex Lattice Design. JPSCR J. Pharm. Sci. Clin. Res. 2, 53–65. https://doi.org/10.20961/jpscr.v2i01.5284
Fitrya, F., Fithry, N.A., Muharni, 2017. A subchronic toxicity test of ethanol extract from Tunjuk langit rhizome (Helminthostachys Zeylanica) on albino rats, Rattus noverticus (Wistar strain). Asian J. Pharm. Clin. Res. 10. https://doi.org/10.22159/ajpcr.2017.v10i2.15563
Fitrya, Fithri, N.A., Untari, B., Aptililianti, 2016. Ethanol Extract Formulation of Tunjuk Langit Rhizome As Tablet By Wet Granulation Method. J. Farm. Galen. Vol. 3, 8–12.
Hardenia, S., Darwhekar, G.., Singh, R.., 2016. Optimization of Fast Dissolving Tablets of Promethazine Theoclate with Effervescent Technology using 32 Full Factorial Design. Int. J. Pharm. Sci. Res. 7, 5115–5124. https://doi.org/10.13040/IJPSR.0975-8232.7(12).5115-24
Huang, Y.L., Shen, C.C., Shen, Y.C., Chiou, W.F., Chen, C.C., 2009. Anti-inflammatory and Antiosteoporosis Flavonoids from the Rhizomes of Helminthostachys zeylanica. J. Nat. Prod. 72, 1273–1278. https://doi.org/10.1021/acs.jnatprod.5b01164
Huang, Y.L., Yeh, P.Y., Shen, C.C., Chen, C.C., 2003. Antioxidant flavonoids from the rhizomes of Helminthostachys zeylanica. Phytochemistry 64, 1277–1283. https://doi.org/10.1016/j.phytochem.2003.09.009
Kadajji, V.G., Betageri, G. V., 2011. Water soluble polymers for pharmaceutical applications. Polymers (Basel). 3, 1972–2009. https://doi.org/10.3390/polym3041972
Kharisma, R., Sari, I.P., Bestari, A.N., 2018. Optimization Formula Tablet Extract of Bengkuang (Pachyrrhizus erosus) Variation Avicel® Ph 101 and Crospovidone. Tradit. Med. J. 23, 9–15.
Kumar, D., Singh, J., Antil, M., Kumar, V., 2016. Quality Control of Tablets: A Review. Int. J. Univers. Pharm. an Bio Sci. 5, 55–67.
Markl, D., Zeitler, J.A., 2017. A Review of Disintegration Mechanisms and Measurement Techniques. Pharm. Res. 34, 890–917. https://doi.org/10.1007/s11095-017-2129-z
Mishra, A., Mishra, A.K., 2019. Development of Herbal Tablet Formulation: Systematic Approach. Altern. Integr. Med. 8, 1–3. https://doi.org/10.2310/psych.1098
Muppalaneni, S., Omidian, H., 2013. Polyvinyl Alcohol in Medicine and Pharmacy: A Perspective. J. Dev. Drugs 02, 1–5. https://doi.org/10.4172/2329-6631.1000112
Rao, B.P., Geetha, M., Purushothama, N., Sanki, U., 2009. Optimization and development of swellable controlled porosity osmotic pump tablet for theophylline. Trop. J. Pharm. Res. 8, 247–255. https://doi.org/10.4314/tjpr.v8i3.44541
Rowe, R.C., Sheskey, P.J., Quinn, M.E., 2009. Handbook of Pharmaceutical Excipient, Sixth. ed. Pharmaceutical Press and American Pharmacists Association, Washington.
Saxena, S.K., 2004. The Joint FAO/WHO Expert Committee on Food Additives, 61st Meeting, in: Polyvinil Alcohol (PVA): Chemical and Technical Assessment (CTA). pp. 1–3.
Son, G.H., Lee, H.J., Na, Y.G., Lee, H.K., Kim, Sung Jin, Huh, H.W., Kim, K.T., Kang, J.S., Kim, Y.H., Myung, C.S., Yoon, M.H., Kim, Seok Jin, Cho, H.S., Lee, J.Y., Cho, C.W., 2019. Formulation and statistical analysis of an herbal medicine tablet containing Morus alba leaf extracts. J. Pharm. Investig. 49, 625–634. https://doi.org/10.1007/s40005-018-00417-9
Su, L.H., Li, Y.P., Li, H.M., Dai, W.F., Liu, D., Cao, L., Li, R.T., 2016. Anti-inflammatory prenylated flavonoids from Helminthostachys zeylanica. Chem. Pharm. Bull. 64, 497–501. https://doi.org/10.1248/cpb.c15-00661
Suja, S.R., Latha, P.G., Pushpangadan, P., Rajasekharan, S., 2004. Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats. J. Ethnopharmacol. 92, 61–66. https://doi.org/10.1016/j.jep.2004.01.019
Wu, K.C., Kao, C.P., Ho, Y.L., Chang, Y.S., 2017. Quality control of the root and rhizome of Helminthostachys zeylanica (Daodi-Ugon) by HPLC using Quercetin and Ugonins as markers. Molecules 22, 1–10. https://doi.org/10.3390/molecules22071115
Zade, P.S., Kawtikwar, P.S., Sakarkar, D.M., 2009. Formulation, evaluation and optimization of fast dissolving tablet containing Tizanidine Hydrochloride. Int. J. PharmTech Res. 1, 34–42.
Authors
Fitrya, F., Fithri, N. A., Untari, B., & Aprililianti. (2021). Tablet Formula Optimization From Helminthostachys Zaylanica Extract Using A Simplex Lattice Design. Science and Technology Indonesia, 6(3), 131–136. https://doi.org/10.26554/sti.2021.6.3.131-136
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