Gastroprotective Effects of Dendropthoe pentandra Leaf Ethanol Extract on Peptic Ulcer Animal Models
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Keywords:
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Dendrophthoe pentandra, Gastroprotektive, Ethanol Extract, Peptic Ulcer
Abstract
Dendrophthoe pentandra (Loranthaceae) is a semi-parasitic plant with several diverse metabolites and biological activities and is widely used in traditional medicine. This study aims to evaluate the gastroprotective effectiveness of the ethanol extract of D. pentandra leaves in animals induced by an acute peptic ulcer with absolute ethanol. The gastroprotective effect of the extract (100, 250 and 500 mg/kg doses) was evaluated through ulcer index parameters, physicochemical properties of gastric fluid, and histopathological analysis. The study results of the study showed that the ethanol extract of D. pentandra leaves at a dose of 500 mg/kg could provide a protective effect equivalent to omeprazole. Histopathological analysis proved the improvement of the mucous membrane structure in the animals pre-treated with the extract. Based on these findings, it can be concluded that the ethanol extract of D. pentandra leaves is effective as an anti-ulcer drug, so it is feasible to be developed as a gastroprotective from herbal.
References
Akomas, S., G. Ezeifeka, and S. Ijioma (2014). Justification for the Use of Musa Paradisiaca Green Fruit Extract for GIT Mucosa Protection and Ulcer Treatment. Continental J. Animal and Veterinary Research, 6; 29–35
Alharits, L., N. M. Hemelda, and W. Handayani (2020). Allelopathic Activity of Dendrophthoe Pentandra as a Potential Bioherbicide to Inhibit Seed Germination and Seedling Growth of Eleusine Indica. Nusantara Bioscience, 12(1); 33–39
Aslam, S., M. A. Tahir, and M. S. Abbasi (2020). Gastro Protective Effect of Grewia optiva (Dhamna) Leaf Extract on Ethanol Induced Gastric Ulcer in Rats. Asian Journal of Research and Reports in Gastroenterology, 4(1); 19–25
Bansal, V. K. and R. K. Goel (2012). Gastroprotective Effect of Acacia Nilotica Young Seedless Pod Extract: Role of Polyphenolic Constituents. Asian Pacific Journal of Tropical Medicine, 5(7); 523–528
De Olinda, T., T. Lemos, L. Machado, V. Rao, and F. Santos (2008). Quebrachitol-induced Gastroprotection Against Acute Gastric Lesions: Role of Prostaglandins, Nitric Oxide and K+ ATP Channels. Phytomedicine, 15(5); 327–333
de Souza, M. C., A. J. Vieira, F. P. Beserra, C. H. Pellizzon, R. H. Nóbrega, and A. L. Rozza (2019). Gastroprotective Effect of Limonene In Rats: Influence on Oxidative Stress, Inflammation and Gene Expression. Phytomedicine, 53; 37–42
Endharti, A. T. and S. Permana (2017). Extract from Mango Mistletoes Dendrophthoe Pentandra Ameliorates TNBS induced Colitis by Regulating CD4+ T Cells in Mesenteric Lymph Nodes. BMC Complementary and Alternative Medicine, 17(1); 1–8
Endharti, A. T., A. Wulandari, A. Listyana, E. Norahmawati, and S. Permana (2016). Dendrophthoe Pentandra (L.) Miq Extract Effectively Inhibits Inflammation, Proliferation and Induces p53
Expression on Colitis-associated Colon Cancer.
Bmc Complementary and Alternative Medicine, 16(1); 1–8
Fitrilia, T., M. Bintang, and M. Safithri (2015). Phytochemical Screening and Antioxidant Activity of Clove Mistletoe Leaf Extract (Dendrophthoe pentandra (l.) Miq.). IOSR Journal of Pharmacy, 5(8); 13–18
Fitrya, F., A. Amriani, R. P. Novita, A. Ahmadi, and R. Nabilah (2022a). Efektivitas Ekstrak Etanol Polong Petai [Parkia speciosa Hassk.] Sebagai Anti Ulcer Pada Tikus Wistar yang Diinduksi Etanol Absolut. Jurnal Sains Farmasi & Klinis, 9(1); 64–70 (In Indonesia)
Fitrya, F., A. Amriani, R. P. Novita, A. Salsabila, S. M. Siregar, and Y. Anafisya (2022b). Evaluation of Ethanol Extracts from Three Species of Artocarpus as Natural Gastroprotective Agents: in Vivo and Histopathological Studies. Journal of Complementary and Integrative Medicine, 19(4); 967–974
Fitrya, F., A. Annisa, S. Nikita, and C. Ranna (2019). Alpha Glukosidase Inhibitory Test and Total Phenolic Content of Ethanol Extract of Parkia Speciosa Plant. Science and Technology Indonesia, 4(1); 1–4
Guzmán-Gómez, O., R. V. García-Rodríguez, L. Quevedo Corona, R. Pérez-Pastén-Borja, N. L. Rivero-Ramírez, E. Ríos-Castro, S. Pérez-Gutiérrez, J. Pérez-Ramos, and G. A. Chamorro-Cevallos (2018). Amelioration of Ethanolinduced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (spirulina) Maxima. Nutrients, 10(6); 763
Halim, S. Z., Z. A. Zakaria, M. H. Omar, N. Mohtarrudin, I. R. A. Wahab, and M. N. H. Abdullah (2017). Synergistic Gastroprotective Activity of Methanolic Extract of a Mixture Of Melastoma Malabathricum and Muntingia Calabura Leaves in Rats. Bmc Complementary and Alternative Medicine, 17; 1–16
Hardiyanti, R., L. Marpaung, I. K. Adnyana, and P. Simanjuntak (2019). Isolation of Quercitrin From Dendrophthoe Pentandra (L.) Miq Leaves and It’s Antioxidant and Antibacterial Activities. Rasayan Journal of Chemistry, 12(3); 1822–1827
Hasan, M., M. T. Ali, R. Khan, P. Palit, A. Islam, V. Seidel, R. Akter, and L. Nahar (2018). Hepatoprotective, Anti-hyperglycemic and Antidiabetic Effects of Dendrophthoe Pentandra Leaf Extract in Rats. Clinical Phytoscience, 4(1); 1–7
Hussaini, J., N. A. Othman, M. A. Abdulla, N. A. Majid, H. M. Faroq, and S. Ismail (2012). Gastroprotective Effects of Dicranopteris Linearis Leaf Extract Against Ethanol-induced Gastric Mucosal Injury in Rats. Scientific Research and Essays, 7(18); 1761–1767
Ijioma, S., E. Nwaogazi, A. Nwankwo, H. Oshilonya, C. Ekeleme, and L. Oshilonya (2018). Histological Exhibition of the Gastroprotective Effect of Moringa Oleifera Leaf Extract. Comparative Clinical Pathology, 27; 327–332
Jincy, J. and C. Sunil (2020). Exploring Antiulcer and Anti-inflammatory Activities of Methanolic Leaves Extract of an Indian Mistletoe Helicantes Elasticus (Desv.) Danser. South African Journal of Botany, 133; 10–16
Karunaratne, R. and D. Uduwela (2020). A Comparison of the Bioactivity of Dendrophthoe Falcata on the Hosts; Limonia Acidissima and Mangifera Indica. Ceylon Journal of Science, 49(2); 159–164
Kong, D., L. Wang, Y. Niu, L. Cheng, B. Sang, D. Wang, J. Tian, W. Zhao, X. Liu, and Y. Chen (2023). Dendrophthoe Falcata (Lf) Ettingsh. and Dendrophthoe Pentandra (L.) Miq.: A Review of Traditional Medical Uses, Phytochemistry, Pharmacology, Toxicity, and Applications. Frontiers in Pharmacology, 14; 1–18
Martinsen, T. C., R. Fossmark, and H. L. Waldum (2019). The Phylogeny and Biological Function of Gastric Juice—microbiological Consequences of Removing Gastric Acid. International Journal of Molecular Sciences, 20(23); 6031
Mu’nisa, A., Y. Hala, A. M. Taiyeb, and D. K. Sari (2019). Effect of Boiled Water Parasite Kapok (Dendrophthoe pentandra) Leaves on Total Cholesterol Levels and Histopathology of Hepar of Hypercholesterolemic Mice. Materials Science Forum, 967; 51–55
Mustarichie, R., S. Warya, N. M. Saptarini, and D. Ramdhani (2015). Total Flavonoid Content and Antiinflammatory Properties of Indonesian Mistletoes (Dendrophtoe pentandra (l.) Miq.) Ethanol Extract. World Journal of Pharmaceutical Research, 4(4); 287–302
Najini, R., M. S. Bachri, and S. Yuliani (2018). The Gastroprotective Effects of Canna Edulis Ker. Tuber Starch on Peptic Ulcer and The Histopathological Profile of Rat Stomach. Pharmaciana, 8(1); 43–52
Park, J. U., J. H. Kang, M. A. A. Rahman, A. Hussain, J. S. Cho, and Y. I. Lee (2019). Gastroprotective Effects of Plants Extracts on Gastric Mucosal Injury In Experimental Spraguedawley Rats. BioMed Research International, 2019; 1–11
Raish, M., M. Shahid, Y. A. Bin Jardan, M. A. Ansari, K. M. Alkharfy, A. Ahad, I. A. Abdelrahman, A. Ahmad, and F. I. Al-Jenoobi (2021). Gastroprotective Effect of Sinapic Acid on Ethanol-induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and Nf-????b Signaling and Antiapoptotic Role. Frontiers in Pharmacology, 12; 622815
Rozza, A. L., F. Meira de Faria, A. R. Souza Brito, and C. H. Pellizzon (2014). The Gastroprotective Effect of Menthol: Involvement of Anti-apoptotic, Antioxidant and Anti-inflammatory Activities. PloS one, 9(1); 1–6
Sahakitpichan, P., W. Disadee, R. Buntawong, N. Chimnoi, S. Ruchirawat, and T. Kanchanapoom (2017). A Furan2-carbonyl C-glucoside and an Alkyl Glucoside from the Parasitic Plant, Dendrophthoe Pentandra. Phytochemistry Letters, 21; 90–93
Sattar, A., A. Abdo, M. N. Mushtaq, I. Anjum, and A. Anjum (2019). Evaluation of Gastro protective Activity of Myristica Fragrans on Ethanol-induced Ulcer in Albino Rats. Anais da Academia Brasileira de Ciências, 91(2); 1–8
Wu, X., Q. Huang, N. Xu, J. Cai, D. Luo, Q. Zhang, Z. Su, C. Gao, and Y. Liu (2018). Antioxidative and Anti inflammatory Effects of Water Extract of Acrostichum Aureum Linn. Against Ethanol induced Gastric Ulcer in Rats. Evidence Based Complementary and Alternative Medicine, 2018; 1–10
Yasin, H., F. Tariq, A. Sameen, N. Ahmad, M. F. Manzoor, M. Yasin, T. Tariq, M. W. Iqbal, B. Ishfaq, and S. Mahmood (2020). Ethanolic Extract of Okra Has a Potential Gastroprotective Effect on Acute Gastric Lesions in Sprague Dawley Rats. Food Science & Nutrition, 8(12); 6691–6698
Yoo, C. Y., H. U. Son, A. Fanar, H. J. Choi, M. B. Alam, and S. H. Lee (2020). Opuntia Humifusa Aqueous Extract Alleviates Ethanol-induced Gastric Ulcer in a Mouse Model. Asian Pacific Journal of Tropical Biomedicine, 10(9); 403
Zakaria, Z. A., T. Balan, S. S. Mamat, N. Mohtarrudin, T. L. Kek, and M. Z. Salleh (2015). Mechanisms of Gastroprotection of Methanol Extract of Melastoma Malabathricum Leaves. BMC Complementary and Alternative Medicine, 15; 1–15
Zhang, W., Y. Lian, Q. Li, L. Sun, R. Chen, X. Lai, Z. Lai, E. Yuan, and S. Sun (2020). Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers. Molecules, 25(20); 4626
Zhou, D., Q. Yang, T. Tian, Y. Chang, Y. Li, L. R. Duan, H. Li, and S. W. Wang (2020). Gastroprotective Effect of Gallic Acid Against Ethanol-induced Gastric Ulcer in Rats: Involvement of the Nrf2/HO-1 Signaling and Antiapoptosis Role. Biomedicine & Pharmacotherapy, 126; 110075
Alharits, L., N. M. Hemelda, and W. Handayani (2020). Allelopathic Activity of Dendrophthoe Pentandra as a Potential Bioherbicide to Inhibit Seed Germination and Seedling Growth of Eleusine Indica. Nusantara Bioscience, 12(1); 33–39
Aslam, S., M. A. Tahir, and M. S. Abbasi (2020). Gastro Protective Effect of Grewia optiva (Dhamna) Leaf Extract on Ethanol Induced Gastric Ulcer in Rats. Asian Journal of Research and Reports in Gastroenterology, 4(1); 19–25
Bansal, V. K. and R. K. Goel (2012). Gastroprotective Effect of Acacia Nilotica Young Seedless Pod Extract: Role of Polyphenolic Constituents. Asian Pacific Journal of Tropical Medicine, 5(7); 523–528
De Olinda, T., T. Lemos, L. Machado, V. Rao, and F. Santos (2008). Quebrachitol-induced Gastroprotection Against Acute Gastric Lesions: Role of Prostaglandins, Nitric Oxide and K+ ATP Channels. Phytomedicine, 15(5); 327–333
de Souza, M. C., A. J. Vieira, F. P. Beserra, C. H. Pellizzon, R. H. Nóbrega, and A. L. Rozza (2019). Gastroprotective Effect of Limonene In Rats: Influence on Oxidative Stress, Inflammation and Gene Expression. Phytomedicine, 53; 37–42
Endharti, A. T. and S. Permana (2017). Extract from Mango Mistletoes Dendrophthoe Pentandra Ameliorates TNBS induced Colitis by Regulating CD4+ T Cells in Mesenteric Lymph Nodes. BMC Complementary and Alternative Medicine, 17(1); 1–8
Endharti, A. T., A. Wulandari, A. Listyana, E. Norahmawati, and S. Permana (2016). Dendrophthoe Pentandra (L.) Miq Extract Effectively Inhibits Inflammation, Proliferation and Induces p53
Expression on Colitis-associated Colon Cancer.
Bmc Complementary and Alternative Medicine, 16(1); 1–8
Fitrilia, T., M. Bintang, and M. Safithri (2015). Phytochemical Screening and Antioxidant Activity of Clove Mistletoe Leaf Extract (Dendrophthoe pentandra (l.) Miq.). IOSR Journal of Pharmacy, 5(8); 13–18
Fitrya, F., A. Amriani, R. P. Novita, A. Ahmadi, and R. Nabilah (2022a). Efektivitas Ekstrak Etanol Polong Petai [Parkia speciosa Hassk.] Sebagai Anti Ulcer Pada Tikus Wistar yang Diinduksi Etanol Absolut. Jurnal Sains Farmasi & Klinis, 9(1); 64–70 (In Indonesia)
Fitrya, F., A. Amriani, R. P. Novita, A. Salsabila, S. M. Siregar, and Y. Anafisya (2022b). Evaluation of Ethanol Extracts from Three Species of Artocarpus as Natural Gastroprotective Agents: in Vivo and Histopathological Studies. Journal of Complementary and Integrative Medicine, 19(4); 967–974
Fitrya, F., A. Annisa, S. Nikita, and C. Ranna (2019). Alpha Glukosidase Inhibitory Test and Total Phenolic Content of Ethanol Extract of Parkia Speciosa Plant. Science and Technology Indonesia, 4(1); 1–4
Guzmán-Gómez, O., R. V. García-Rodríguez, L. Quevedo Corona, R. Pérez-Pastén-Borja, N. L. Rivero-Ramírez, E. Ríos-Castro, S. Pérez-Gutiérrez, J. Pérez-Ramos, and G. A. Chamorro-Cevallos (2018). Amelioration of Ethanolinduced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (spirulina) Maxima. Nutrients, 10(6); 763
Halim, S. Z., Z. A. Zakaria, M. H. Omar, N. Mohtarrudin, I. R. A. Wahab, and M. N. H. Abdullah (2017). Synergistic Gastroprotective Activity of Methanolic Extract of a Mixture Of Melastoma Malabathricum and Muntingia Calabura Leaves in Rats. Bmc Complementary and Alternative Medicine, 17; 1–16
Hardiyanti, R., L. Marpaung, I. K. Adnyana, and P. Simanjuntak (2019). Isolation of Quercitrin From Dendrophthoe Pentandra (L.) Miq Leaves and It’s Antioxidant and Antibacterial Activities. Rasayan Journal of Chemistry, 12(3); 1822–1827
Hasan, M., M. T. Ali, R. Khan, P. Palit, A. Islam, V. Seidel, R. Akter, and L. Nahar (2018). Hepatoprotective, Anti-hyperglycemic and Antidiabetic Effects of Dendrophthoe Pentandra Leaf Extract in Rats. Clinical Phytoscience, 4(1); 1–7
Hussaini, J., N. A. Othman, M. A. Abdulla, N. A. Majid, H. M. Faroq, and S. Ismail (2012). Gastroprotective Effects of Dicranopteris Linearis Leaf Extract Against Ethanol-induced Gastric Mucosal Injury in Rats. Scientific Research and Essays, 7(18); 1761–1767
Ijioma, S., E. Nwaogazi, A. Nwankwo, H. Oshilonya, C. Ekeleme, and L. Oshilonya (2018). Histological Exhibition of the Gastroprotective Effect of Moringa Oleifera Leaf Extract. Comparative Clinical Pathology, 27; 327–332
Jincy, J. and C. Sunil (2020). Exploring Antiulcer and Anti-inflammatory Activities of Methanolic Leaves Extract of an Indian Mistletoe Helicantes Elasticus (Desv.) Danser. South African Journal of Botany, 133; 10–16
Karunaratne, R. and D. Uduwela (2020). A Comparison of the Bioactivity of Dendrophthoe Falcata on the Hosts; Limonia Acidissima and Mangifera Indica. Ceylon Journal of Science, 49(2); 159–164
Kong, D., L. Wang, Y. Niu, L. Cheng, B. Sang, D. Wang, J. Tian, W. Zhao, X. Liu, and Y. Chen (2023). Dendrophthoe Falcata (Lf) Ettingsh. and Dendrophthoe Pentandra (L.) Miq.: A Review of Traditional Medical Uses, Phytochemistry, Pharmacology, Toxicity, and Applications. Frontiers in Pharmacology, 14; 1–18
Martinsen, T. C., R. Fossmark, and H. L. Waldum (2019). The Phylogeny and Biological Function of Gastric Juice—microbiological Consequences of Removing Gastric Acid. International Journal of Molecular Sciences, 20(23); 6031
Mu’nisa, A., Y. Hala, A. M. Taiyeb, and D. K. Sari (2019). Effect of Boiled Water Parasite Kapok (Dendrophthoe pentandra) Leaves on Total Cholesterol Levels and Histopathology of Hepar of Hypercholesterolemic Mice. Materials Science Forum, 967; 51–55
Mustarichie, R., S. Warya, N. M. Saptarini, and D. Ramdhani (2015). Total Flavonoid Content and Antiinflammatory Properties of Indonesian Mistletoes (Dendrophtoe pentandra (l.) Miq.) Ethanol Extract. World Journal of Pharmaceutical Research, 4(4); 287–302
Najini, R., M. S. Bachri, and S. Yuliani (2018). The Gastroprotective Effects of Canna Edulis Ker. Tuber Starch on Peptic Ulcer and The Histopathological Profile of Rat Stomach. Pharmaciana, 8(1); 43–52
Park, J. U., J. H. Kang, M. A. A. Rahman, A. Hussain, J. S. Cho, and Y. I. Lee (2019). Gastroprotective Effects of Plants Extracts on Gastric Mucosal Injury In Experimental Spraguedawley Rats. BioMed Research International, 2019; 1–11
Raish, M., M. Shahid, Y. A. Bin Jardan, M. A. Ansari, K. M. Alkharfy, A. Ahad, I. A. Abdelrahman, A. Ahmad, and F. I. Al-Jenoobi (2021). Gastroprotective Effect of Sinapic Acid on Ethanol-induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and Nf-????b Signaling and Antiapoptotic Role. Frontiers in Pharmacology, 12; 622815
Rozza, A. L., F. Meira de Faria, A. R. Souza Brito, and C. H. Pellizzon (2014). The Gastroprotective Effect of Menthol: Involvement of Anti-apoptotic, Antioxidant and Anti-inflammatory Activities. PloS one, 9(1); 1–6
Sahakitpichan, P., W. Disadee, R. Buntawong, N. Chimnoi, S. Ruchirawat, and T. Kanchanapoom (2017). A Furan2-carbonyl C-glucoside and an Alkyl Glucoside from the Parasitic Plant, Dendrophthoe Pentandra. Phytochemistry Letters, 21; 90–93
Sattar, A., A. Abdo, M. N. Mushtaq, I. Anjum, and A. Anjum (2019). Evaluation of Gastro protective Activity of Myristica Fragrans on Ethanol-induced Ulcer in Albino Rats. Anais da Academia Brasileira de Ciências, 91(2); 1–8
Wu, X., Q. Huang, N. Xu, J. Cai, D. Luo, Q. Zhang, Z. Su, C. Gao, and Y. Liu (2018). Antioxidative and Anti inflammatory Effects of Water Extract of Acrostichum Aureum Linn. Against Ethanol induced Gastric Ulcer in Rats. Evidence Based Complementary and Alternative Medicine, 2018; 1–10
Yasin, H., F. Tariq, A. Sameen, N. Ahmad, M. F. Manzoor, M. Yasin, T. Tariq, M. W. Iqbal, B. Ishfaq, and S. Mahmood (2020). Ethanolic Extract of Okra Has a Potential Gastroprotective Effect on Acute Gastric Lesions in Sprague Dawley Rats. Food Science & Nutrition, 8(12); 6691–6698
Yoo, C. Y., H. U. Son, A. Fanar, H. J. Choi, M. B. Alam, and S. H. Lee (2020). Opuntia Humifusa Aqueous Extract Alleviates Ethanol-induced Gastric Ulcer in a Mouse Model. Asian Pacific Journal of Tropical Biomedicine, 10(9); 403
Zakaria, Z. A., T. Balan, S. S. Mamat, N. Mohtarrudin, T. L. Kek, and M. Z. Salleh (2015). Mechanisms of Gastroprotection of Methanol Extract of Melastoma Malabathricum Leaves. BMC Complementary and Alternative Medicine, 15; 1–15
Zhang, W., Y. Lian, Q. Li, L. Sun, R. Chen, X. Lai, Z. Lai, E. Yuan, and S. Sun (2020). Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers. Molecules, 25(20); 4626
Zhou, D., Q. Yang, T. Tian, Y. Chang, Y. Li, L. R. Duan, H. Li, and S. W. Wang (2020). Gastroprotective Effect of Gallic Acid Against Ethanol-induced Gastric Ulcer in Rats: Involvement of the Nrf2/HO-1 Signaling and Antiapoptosis Role. Biomedicine & Pharmacotherapy, 126; 110075
Authors
Fitrya, F., Amriani, A. ., Novita, R. P. ., & Kurnia, F. . (2023). Gastroprotective Effects of Dendropthoe pentandra Leaf Ethanol Extract on Peptic Ulcer Animal Models. Science and Technology Indonesia, 8(3), 382–387. https://doi.org/10.26554/sti.2023.8.3.382-387
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